Embedded Files
Electrooxidative C(sp3)‒H Cyanation of Sparteine and Lupanine in Undivided Batch and Continuous-Flow Cells
Raquel M. Durão, Duarte B. Clemente, Abdullahi A. Muiz, Sara Lima, Daniel F. Carvalho, Stijn De Vos, Rita de Jesus, Andreia Fortuna, Carlos A. M. Afonso, Jaime A. S. Coelho
Data-Driven Discovery of a New Fluorescent BASHY Dye for Bioimaging
João M. J. M. Ravasco, João Felicidade, Maria V. Pinto, Fábio M. F. Santos, René González-Campos, Jesús F. Arteaga, Manon Mehraz, Christelle Langevin, Adelaide Fernandes, Ha-Chi Nguyen, David Y. W. Ng, Jaime A. S. Coelho, Uwe Pischel, Pedro M. P. Gois
Dual FGFR-targeting and pH-activable Ruthenium-Peptide Conjugates for targeted therapy of Breast Cancer
João F. Machado, Marco Sá, Inês Pires, Miguel T. Silva, Fernanda M. Marques, Jaime A. S. Coelho, Filipa Mendes, M. Fátima M. Piedade, Miguel Machuqueiro, María A. Jiménez, Maria H. Garcia, João D. G. Correia, Tânia. S. Morais
Macrocyclic Dual-Locked “Turn-On” Drug for Selective and Traceless Release in Cancer Cells
Dominik Schauenburg, Bingjie Gao, Léa N. C. Rochet, Darijan Schüler, Jaime A. S. Coelho, David Y. W. Ng, Vijay Chudasama, Seah L. Kuan, Tanja Weil
Angew. Chem. Int. Ed., 2024, e202314143
+ ChemRxiv
A Historical Review of the Total Synthesis of Natural Products Developed in Portugal
Duarte B. Clemente, Jaime A. S. Coelho
Functionalized cyclopentenones with low electrophilic character as new anticancer agents
Késsia H. S. Andrade, Jaime A. S. Coelho, Raquel Frade, Ana M. Madureira, João P. M. Nunes, Stephen Caddick, Rafael F. A. Gomes, Carlos A. M. Afonso
Practical Synthesis and Biological Screening of Sulfonyl hydrazides
João Macara, Catarina Caldeira, José Cunha, Jaime A. S. Coelho, Maria J. S. A. Silva, Konrad Krämer, Christoph W. Grathwol, Stefan Bräse, M. Manuel B. Marques
Upgrading furanic platforms to α-enaminones: tunable continuous flow hydrogenation of bio-based cyclopentenones
Lídia A. S. Cavaca, Jaime A. S. Coelho, Susana D. Lucas, Rui M. S. Loureiro, Rafael F. A. Gomes, Carlos A. M. Afonso
Detection of Few Hydrogen Peroxide Molecules using Self-Reporting Fluorescent Nanodiamond Quantum Sensors
Yingke Wu, Priyadharshini Balasubramanian, Zhenyu Wang, Jaime A. S. Coelho, Mateja Prslja, Martin B. Plenio, Fedor Jelezko, Tanja Weil
J. Am. Chem. Soc., 2022, 144, 12642–12651
+ ChemRxiv
Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived δ-Lactone-Fused Cyclopentenones
Rafael F. A. Gomes, Joao M. J. M. Ravasco, Késsia H. S. Andrade, Jaime A. S. Coelho, Rui Moreira, Rafael Oliveira, Fátima Nogueira, Carlos A. M. Afonso
Hypervalent Iodine(III) Reagents with Transferable Primary Amines: Structure and Reactivity on the Electrophilic α-Amination of Stabilized Enolates
Diogo L. Poeira, Ana Cláudia R. Negrão, Hélio Faustino, Jaime A. S. Coelho, Clara S. B. Gomes, Pedro M. P. Gois, M. Manuel B. Marques
Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments
Maksymilian M. Zegota, Michael A. Müller, Bellinda Lantzberg, Gönül Kizilsavas, Jaime A. S. Coelho, Pierpaolo Moscariello, María Martínez-Negro, Svenja Morsbach, Pedro M. P. Gois, Manfred Wagner, David Y. W. Ng, Seah Ling Kuan, and Tanja Weil
J. Am. Chem. Soc., 2021, 143, 17047–17058
+ ChemRxiv
PEG-Supported Hypervalent Iodine Reagent for Sulfonamide Synthesis
João Macara, Diogo L. Poeira, Jaime A. S. Coelho, M. Manuel B. Marques
Synthesis of Non-symmetrical Dispiro 1,2,4,5-Tetraoxanes and 1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid
Patrícia S. M. Amado, Luís M. T. Frija, Jaime A. S. Coelho, Paul M. O'Neill, Maria L. S. Cristiano
Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides
Maria J. S. A. Silva, Hélio Faustino, Jaime A. S. Coelho, Maria V. Pinto, Adelaide Fernandes, Ismael Compañón, Francisco Corzana, Gilles Gasser, Pedro M. P. Gois
Securing a furan‐based biorefinery: disclosing the genetic basis of the degradation of hydroxymethylfurfural and its derivatives in the model fungus Aspergillus nidulans
Celso Martins, Diego O. Hartmann, Adélia Varela, Jaime A. S. Coelho, Pedro Lamosa, Carlos A. M. Afonso, Cristina S. Pereira
Predictive Multivariate Models for Bioorthogonal Inverse-Electron Demand Diels-Alder Reactions
Joao M. J. M. Ravasco, Jaime A. S. Coelho
Enantioselective Kinetic Resolution/Desymmetrization of para-Quinols: A Case Study in Boronic-Acid-Directed Phosphoric Acid Catalysis
Banruo Huang, Ying He, Mark D. Levin, Jaime A. S. Coelho, Robert G. Bergman, F. Dean Toste
Solvent-free Synthesis of 2,5-Bis((dimethylamino)methylene)cyclopentanone
Inês S. Martins, Jaime A. S. Coelho
Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes
Marco Hebel, Andreas Riegger, Jasmina Gačanin, Maksymilian Zegota, Michaela Pieszka, Thorsten Lückerath, Jaime A. S. Coelho, Manfred Wagner, Pedro M. P. Gois, David Y. W. Ng, Tanja Weil
Synthesis and reactivity/stability study of double-functionalizable strained trans-cyclooctenes for tetrazine bioorthogonal reactions
Joao M. J. M. Ravasco, Jaime A. S. Coelho, Alexandre F. Trindade, Carlos A. M. Afonso
Hypervalent Iodine Mediated Sulfonamide Synthesis
Diogo L. Poeira, João Macara, Hélio Faustino, Jaime A. S. Coelho, Pedro M. P. Gois, M. Manuel B. Marques
Direct Conversion of Activated 5-Hydroxymethylfurfural into δ-Lactone-fused Cyclopentenones
Rafael F. A. Gomes, Jaime A. S. Coelho, Carlos A. M. Afonso
Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions
Jaime A. S. Coelho, Akira Matsumoto, Manuel Orlandi, Margaret J. Hilton, Matthew S. Sigman, F. Dean Toste
Valorization of Oleuropein via Tunable Acid-Promoted Methanolysis
Lídia A. S. Cavaca, Catarina A. B. Rodrigues, Svilen P. Simeonov, Rafael F. A. Gomes, Jaime A. S. Coelho, Gustavo P. Romanelli, Angel G. Sathicq, José J. Martínez, Carlos A. M. Afonso
Modern Approaches for Asymmetric Construction of Carbon-Fluorine Quaternary Stereogenic Centers; Synthetic Challenges and Pharmaceutical Needs
Yi Zhu, Jianlin Han, Jiandong Wang, Norio Shibata, Mikiko Sodeoka, Vadim Soloshonok, Jaime A. S. Coelho, F. Dean Toste
Synthesis and applications of Stenhouse salts and derivatives
Rafael F. A. Gomes, Jaime A. S. Coelho, Carlos A. M. Afonso
Copper(II) triflates as reusable catalyst for the synthesis of trans-4,5-diamino-cyclopent-2-enones in water
Rafael F. A. Gomes, Nuno R. Esteves, Jaime A. S. Coelho, Carlos A. M. Afonso
Parameterization of Noncovalent Interactions for Transition State Interrogation Applied to Asymmetric Catalysis
Manuel Orlandi, Jaime A. S. Coelho, Margaret J. Hilton, F. Dean Toste, Matthew S. Sigman
Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF)
Ana I. Vicente, Jaime A. S. Coelho, Svilen P. Simeonov, Hristina I. Lazarova, Margarita D. Popova and Carlos A. M. Afonso
Bifunctional Cr3+ modified ion exchange resins as efficient reusable catalysts for the production and isolation of 5-hydroxymethylfurfural from glucose
Joao M. J. M. Ravasco, Jaime A. S. Coelho, Svilen P. Simeonov, Carlos A. M. Afonso
Evaluating the toxicity of biomass derived platform chemicals
Sónia P. M. Ventura, Paulo de Morais, Jaime A. S. Coelho, Tânia Sintra, João A. P. Coutinho, Carlos A. M. Afonso
Synthesis of 5-(hydroxymethyl)furfural
Svilen P. Simeonov, Jaime A. S. Coelho, Carlos A. M. Afonso
Synthesis of Symmetric Bis(N‑alkylaniline)triarylmethanes via Friedel−Crafts-Catalyzed Reaction between Secondary Anilines and Aldehydes
Rafael F. A. Gomes, Jaime A. S. Coelho, Raquel F. M. Frade, Alexandre F. Trindade, Carlos A. M. Afonso
Trienamines derived from 5-substituted furfurals: remote ε-functionalization of 2,4-dienals
Jaime A. S. Coelho, Alexandre F. Trindade, Raquel F. M. Frade, Vânia André, M. Teresa Duarte, Luis F. Veiros, Carlos A. M. Afonso
An emerging platform from renewable resources: selection guidelines for human exposure of furfural-related compounds
Raquel F. M. Frade, Jaime A. S. Coelho, Svilen P. Simeonov, Carlos A. M. Afonso
NHC-catalysed direct addition of HMF to diazo compounds: synthesis of acyl hydrazones with antitumor activity
João P. M. António, Raquel F. M. Frade, Fábio M. F. Santos, Jaime A. S. Coelho, Carlos A. M. Afonso, Pedro M. P. Gois, Alexandre F. Trindade
N-Heterocyclic Carbene Dirhodium(II) Complexes as Catalysts for Allylic and Benzylic Oxidations
Jaime A. S. Coelho, Alexandre F. Trindade, Riccardo Wanke, Bruno G. M. Rocha, Luis F. Veiros, Pedro M. P. Gois, Armando J. L. Pombeiro, Carlos A. M. Afonso
Integrated Chemo-Enzymatic Production of 5-Hydroxymethylfurfural from Glucose
Svilen P. Simeonov, Jaime A. S. Coelho, Carlos A. M. Afonso
An Integrated Approach for the Production and Isolation of 5-Hydroxymethylfurfural from Carbohydrates
Svilen P. Simeonov, Jaime A. S. Coelho, Carlos A. M. Afonso
Fine Tuning of Dirhodium(II) Complexes: Exploring the Axial Modification
Alexandre F. Trindade, Jaime A. S. Coelho, Carlos A. M. Afonso, Luis F. Veiros, Pedro M. P. Gois
Bringing an “Old” Biological Buffer to Coordination Chemistry: New 1D and 3D Coordination Polymers with [Cu4(Hbes)4] Cores for Mild Hydrocarboxylation of Alkanes
Alexander M. Kirillov, Jaime A. S. Coelho, Marina V. Kirillova, M. Fátima C. Guedes da Silva, Dmytro S. Nesterov, Katrin R. Gruenwald, Matti Haukka, Armando J. L. Pombeiro
Book Editor
Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, Royal Society of Chemistry 2016
Eds. Carlos A. M. Afonso, Robert Franzén, Bin Tan, Nuno R. Candeias, Dulce Simão, Alexandre Trindade and Jaime A. S. Coelho
Book chapters
i) Preparation of 4,5-functionalized cyclopentenone via cyclization of Stenhouse adduct and ii) Regioselective catalytic transfer hydrogenation of citral,
Jaime A. S. Coelho and Carlos A. M. Afonso
Comprehensive Organic Chemistry Experiments for the Laboratory Classroom 2016, RSC Eds. Carlos A. M. Afonso, Robert Franzén, Bin Tan, Nuno R. Candeias, Dulce Simão, Alexandre Trindade and Jaime A. S. Coelho, ISBN 9781849739634. Link
Hidrogenação Catalítica e Regiosseletiva de Olefinas por Transferência de Hidrogénio, Exp. 27,
Carlos A. M. Afonso, Jaime A. S. Coelho and Filipe M. C. Menezes
100 Experiências de Química Orgânica, Lisbon, IST Press, 2011. Eds. Carlos A. M. Afonso, Dulce P. Simão, Luísa P. Ferreira, Maria E. S. Serra and Maria M. M. Raposo, ISBN: 978-989-8481-09-2. Link
Non-Peer Reviewed Journal Articles
Criando Diversidade Estrutural a Partir de Biomassa: de Furanos a Ciclopentenonas Complexas
Rafael F. A. Gomes, Nuno R. Esteves, Jaime A. S. Coelho, Svilen P. Simeonov, Carlos A. M. Afonso
Boletim da Sociedade Portuguesa de Química (SPQ), 2020, 44, 129
5-Hidroximetilfurfural: plataforma para obtenção de diversidade molecular
Alexandre F. Trindade, Jaime A. S. Coelho, Rafael F. A. Gomes, João P. M. António, Carlos A. M. Afonso
Boletim da Sociedade Portuguesa de Química (SPQ) (Portugal), 2019, 42, 236
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